Caricamento
Ebri.it



Presidente

ANTONINO CATTANEO

Dopo la laurea in Fisica all'Università La Sapienza, Antonino Cattaneo è  stato perfezionando alla Scuola Normale Superiore di Pisa, sotto la  supervisione  del Prof. Lamberto Maffei. In seguito ha lavorato come postdoc e poi come ricercatore con Rita Levi-Montalcini (premio Nobel per la Medicina per la scoperta del NGF) all’Istituto di Neurobiologia di Roma del CNR, e con Cesar Milstein (premio Nobel per la Medicina per la scoperta degli anticorpi monoclonali) all’Istituto MRC di Cambridge in Inghilterra. Dal 1991 al 2008 è stato professore ordinario di Biofisica alla Scuola internazionale di studi avanzati (SISSA) di Trieste, dove è stato direttore di Dipartimento dal 1991 al 1995 e Direttore in carica della SISSA dal 1996 al 2001. Dal 2008 e professore ordinario di Neurobiologia alla Scuola Normale Superiore (Pisa) e Direttore del laboratorio di Biologia BioSnS.

Antonino Cattaneo è autore di numerose pubblicazioni in riviste scientifiche internazionali “peer-reviewed”, ed è stato insignito di numerosi riconoscimenti e premi scientifici quali il “Premio Domenico Marotta” dell’ Accademia Nazionale delle Scienze detta dei XL, la “Medaglia W. Jansenius” dell’Accademia Slovacca delle Scienze ed il Premio Internazionale “G. Tartufari” per la Biologia dall’Accademia Nazionale dei Lincei. E’ membro dell’EMBO (European Molecular Biology Organization) e membro dell’Accademia Nazionale delle Scienze detta dei XL. E’ stato membro del Consiglio degli Scienziati del HFSPO (Human Frontier Science Program Organization), organizzazione nella quale ha presieduto per quattro anni la Commissione valutatrice per l’assegnazione dei finanziamenti di ricerca. E’ stato Visiting Fellow del Trinity College in Cambridge (UK). E’ team leader del Network dei giovani ricercatori dell’Istituto Europeo di Neuroscienze.

Precedenti posizioni:

  • 1995-1997      MRC Laboratory of Molecular Biology (Cambridge UK) (Principal Investigator, on sabbatical leave from SISSA)
  • 1991-2008      Full Professor of Biophysics, International School for Advanced Studies (SISSA) (Trieste)
  • 1990-1991      Associate Professor of Biophysics, University of Roma La Sapienza
  • 1987-1990      Associate Professor of Physiology, University of Naples and Group Leader at the the CNR Institute of Neurobiology (Rome).
  • 1985-1987 MRC Laboratory of Molecular Biology (Cambridge, UK). Junior scientist, holding a Long Term EMBO Fellowship, working with Michael Neuberger and Cesar Milstein (Nobel Awardee)
  • 1980-1985      CNR Institute of Neurobiology (Rome) Post doc with Pietro Calissano and Nobel Laureate Rita Levi-Montalcini

Premi e riconoscimenti:

  • 1984               Member of the Senior Combination Room at Gonville and Caius College (Cambridge, UK)
  • 1985-1987      Visiting Fellow at Clare Hall College (Cambridge, UK) and Life Member
  • 1991               Member of the European Molecular Biology Organization (EMBO)
  • 1994-1997     Human Science Frontier Organization (HFSPO). Member of the HFSPO Grants Review Committee, Brain Section (served for two years as the Chairman)
  • 1997-1999     Member of the HFSPO Council of Scientists.
  • 1994              The Domenico Marotta Prize, Accademia Nazionale delle Scienze detta dei XL
  • 1996              The W. Jansenius Medal, Slovak Academy of Sciences
  • 2008              The “G.Tartufari” International Prize for Biology, Accademia Nazionale dei Lincei
  • 2008              Visiting Fellow Commoner, Trinity College (Cambridge University, UK) (Michaelmas Term)
  • 2009              Elected member of the Accademia Nazionale delle Scienze detta dei XL
  • 2011              Neuron Innovation Award (Gene Expression Systems Inc and Appasani Research Institute)
  • 2012              The Pericles Internazional Prize
  • 2013              Visiting Fellow Commoner, Trinity College (Cambridge University, UK)
  • 2014              The Giorgio Careri Lecture (Universita' La Sapienza, Roma (Italy))
  • 2018              Elected member of the Accademia Nazionale dei Lincei

Breve lista degli articoli maggiormente rappresentativi (20 di oltre 205):

  1. Biocca S, Neuberger MS, Cattaneo A (1990) Expression and targeting of intracellular antibodies in mammalian cells. EMBO J 9:101-108.

  2. Piccioli P, Ruberti F, Biocca S, Di Luzio A, Werge TM, Bradbury A, Cattaneo A (1991) Neuroantibodies: molecular cloning of a monoclonal antibody against substance P for expression in the central nervous system. Proc Natl Acad Sci U S A 88:5611-5615.

  3. Tavladoraki P, Benvenuto E, Trinca S, De Martinis D, Cattaneo A, Galeffi P (1993) Transgenic expressing a functional single-chain Fv antibody are specifically protected from virus attack. Nature 366:469-472.

  4. Bradbury A, Persic L, Werge T, Cattaneo A (1993) Use of living columns to select specific phage antibodies. Nature Biotechnology 11:1565-1569.

  5. Berardi N, Cellerino A, Domenici L, Fagiolini M, Pizzorusso T, Cattaneo A, Maffei L (1994) Monoclonal antibodies to nerve growth factor affect the postnatal development of the visual system. Proc Natl Acad Sci U S A 91:684-688.

  6. Biocca S, Pierandrei-Amaldi P, Campioni N and Cattaneo A (1994) Intracellular immunization with cytosolic recombinant antibodies. Nature Biotechnology 12:396-399.

  7. Piccioli P, Di Luzio A, Amann R, Schuligoi R, Surani MA, Donnerer J, Cattaneo A (1995) Neuroantibodies: ectopic expression of a recombinant anti-substance P antibody in the central nervous system of transgenic mice. Neuron 15:373-384.

  8. Biocca S, Ruberti F, Tafani M, Pierandrei-Amaldi P and Cattaneo A (1995) Redox state of single chain Fv fragments targeted to the endoplasmic reticulum, cytosol and mitochondria. Nature Biotechnology 13:1110-1115.

  9. Tongiorgi E, Righi M, Cattaneo A (1997) Activity-dependent dendritic targeting of BDNF and TrkB mRNAs in hippocampal neurons. J Neurosci 17:9492-9505.

  10. Righi M, Tongiorgi E and Cattaneo A (2000) Brain-derived neurotrophic factor (BDNF) induces dendritic targeting of BDNF and tyrosine kinase B mRNAs in hippocampal neurons through a phosphatidylinositol-3 kinase-dependent pathway. J Neurosci 20:3165-3174.

  11. Visintin M, Tse E, Axelson H, Rabbitts TH, Cattaneo A (1999) Selection of antibodies for intracellular function using a two-hybrid in vivo system. Proc Natl Acad Sci U S A 96:11723-11728.

  12. Pesavento E, Margotti E, Righi M, Cattaneo A, Domenici L (2000) Blocking the NGF- TrkA interaction rescues the developmental loss of LTP in the rat visual cortex: role of the cholinergic system. Neuron 25:165-175.

  13. Capsoni S, Ugolini G, Comparini A, Ruberti F, Berardi N, Cattaneo A (2000) Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Proc Natl Acad Sci U S A 97:6826-6831.

  14. Capsoni S, Giannotta S, Cattaneo A (2002) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice. Proc Natl Acad Sci U S A 99:12432-12437.

  15. De Rosa R, Garcia AA, Braschi C, Capsoni S, Maffei L, Berardi N, Cattaneo A (2005) Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice. Proc Natl Acad Sci U S A 102:3811-3816.

  16. Ugolini G, Marinelli S, Covaceuszach S, Cattaneo A, Pavone F (2007) The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain. Proc.Natl Acad Sci USA 104: 2985-2990.

  17. Capsoni, S., Tiveron, C., Amato, G., Vignone, D., Cattaneo, A. (2010) Dissecting the involvement of Tropomyosin kinase A and p75 neurotrophin receptor signaling in NGF deficit-induced neurodegeneration. Proc Natl Acad Sci USA 107: 12299-12304.

  18. Tiveron C et al (2013) proNGF/NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice. Cell Death and Differ., 20(8):1017-30. doi: 10.1038/cdd.2013.22

  19. Meli G, Lecci A, Manca A, Krako N, Albertini V, Benussi L, Ghidoni R, Cattaneo A. (2014) Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum. Nature Commun. 2014 May 27;5:3867. doi: 10.1038/ncomms4867. Highlighted in Alzforum.org.

  20. Capsoni S, Malerba F, Carucci N, Rizzi C, Criscuolo C, Origlia N, Calvello MA, Viegi A, Meli G and Cattaneo A (2016) The chemokine CXCL12 mediates the anti- amyloidogenic actions of painless human Nerve Growth Factor. BRAIN, 140 (1): 201-217. doi:https://doi.org/10.1093/brain/aww271. Editorial highlight.

  21. Chirichella M, Lisi S, Fantini M, Goracci M, Calvello M, Brandi R, Arisi I, D'Onofrio  M, Di Primio C, Cattaneo A. (2017) Post-translational selective intracellular silencing of acetylated proteins with de novo selected intrabodies. Nat Methods. 2017 Mar;14(3):279-282. doi: 10.1038/nmeth.4144. Highlighted and commentd in Biocentury.

  22. Gobbo F, Marchetti L, Jacob A, Pinto B, Binini N, Pecoraro Bisogni F, Alia C, Luin S, Caleo M, Fellin T, Cancedda L and Cattaneo A (2017) Activity-dependent expression of Channelrhodopsin at neuronal synapses. Nature Comm. 8, 1629. DOI: 10.1038/s41467- 017-01699-7. Editorial highlight in Nat Comm.